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Administration of glucagon may be helpful for severe cardiovascular instability associated with Beta-blocker toxicity that is refractory to standard measures, including vasopressors. What is the recommended dose?
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The recommended dose of glucagon is a bolus of 3 to 10 mg, administered slowly over 3 to 5 minutes, followed by an infusion of 3 to 5 mg/h (0.05 to 0.15 mg/kg followed by an infusion of 0.05 to 0.10 mg/kg/hr). (Circulation,122:S829-S861).