Angioedema

Angioedema
All severe cases
[ ] Benadryl 25-50 mg IV
[ ] Cimetidine 300 mg IV
[ ] Solumedrol 125 mg IV
[ ] Epinephrine 0.3 mg IM
[ ] pt on Beta Blockers? add Glucagon
- 1-2 mg IV/IM q5min to effect
- or 1 mg IVP f/b gtt at 2 mg/hr

- hereditary angioedema:
- Treat with C1-INH concentrate (derived from plasma), ecallantide, or icatibant
- May also treat with Transexamic Acid

[ ] C1-INH concentrate 20 U/kg
[ ] Ecallantide (Kalbitor) 30 mg SQ x 1 (inhibits kallikrein from generating bradykinin)
[ ] Icatibant (bradykinin blocker), given SQ, may be carried by patient and given prior to arrival
[ ] TXA 25 mg/kg/dose PO/IV
[ ] Check levels of C4, C1q, and C1 esterase inhibitor (C1-INH) protein quant & also function

- acquired angioedema (usually ACE inhibitors)
[ ] Consider FFP

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